General Public Health

HEMOTHERAPY-RELATED ADVERSE DRUG REACTIONS AND ITS ASSOCIATED FACTORS AMONG ADULT CANCER PATIENTS WHO WERE ON TREATMENT AT Hon. DR. ARTIST ALI BIRA MEMORIAL CANCER TREATMENT CENTER HIWOT FANA COMPERHENSIVE SPECIALIZED HOSPITAL, HARAR, EASTERN ETHIOPIA

Sun, 01 Sep 2024 00:00:00 GMT

HEMOTHERAPY-RELATED ADVERSE DRUG REACTIONS AND ITS ASSOCIATED FACTORS AMONG ADULT CANCER PATIENTS WHO WERE ON TREATMENT AT Hon. DR. ARTIST ALI BIRA MEMORIAL CANCER TREATMENT CENTER HIWOT FANA COMPERHENSIVE SPECIALIZED HOSPITAL, HARAR, EASTERN ETHIOPIA Fekadu Megersa; Shambel Nigussie ( Assist Profe); Bisrat Hagos (Assist Profes) Anticancer drugs account to high susceptibility towards adverse drug reactions due to their narrow therapeutic window and increased toxicity, which makes pharmacovigilance studies essential for prevention, diagnosis, reporting and management in current clinical practice. Objective: To assess the chemotherapy-related adverse drug reactions and associated factors among adult cancer patients who are on treatment at Hon. Dr. Ali Birra cancer treatment center of Hiwot Fana Comprehensive Specialized Hospital, Eastern Ethiopia from July 10 to August 15, 2024. Methods: A hospital-based cross-sectional study was conducted among 422 adult cancer patients who are on treatment at Hiwot Fana Comprehensive Specialized Hospital. All patients on chemotherapy treatment were included in the study. Data was collected by patient interview and medical record review. The collected data was cleaned, coded, and entered into using Kobo tool box and exported to Statistical Package for Social Science version 20.0 for analysis. With Factors significantly associated were identified using logistic regression model at P-value < 0.05 and 95%CI.From 422 study participants, 251 (59.5%) of them were females. Overall, 48.34% (95% CI: 43.6 – 53.6) of the included cancer patients developed chemotherapy related adverse drug reactions. Accordingly, for the Naranjo algorithm, of 2823 ADRs identified, probable account for 2122 (75.17%) followed by definite 508 (18.0%). Based on Hartwig severity assessment scale, majority ADRs were 2699 (95.87%) moderate. Cancer patients with weight of less than 50kg (AOR = 3.29, 95% CI: 1.82, 5.94), cancer patients with age range of 31- 40 years (AOR = 0.34% CI: 0.15, 0.74) were more likely associated with adverse drug reactions. Conclusion: Overall, near to half of the included cancer patients developed ADRs. Having weight less 50 kg, and cancer patient with age range of 31- 40 years were associated with developing ADR. Therefore, special attention should be given for cancer patients with those condition so that adverse drug reactions can be minimized 59p.

Prevalence, Treatment Outcome and Associated Factors of Deep Vein Thrombosis Among Patients Visiting Hiwot Fana Specialized University Hospital, Harar, Eastern Ethiopia, 2024

Sun, 01 Dec 2024 00:00:00 GMT

Prevalence, Treatment Outcome and Associated Factors of Deep Vein Thrombosis Among Patients Visiting Hiwot Fana Specialized University Hospital, Harar, Eastern Ethiopia, 2024 Amanuel Assefa; Dr. Melaku Getachew; Dr. Natan Muluberhan Venous thromboembolism is the third common vascular disease after coronary artery disease and stroke. Which is experienced by 2-5% of people during their lifetime. The condition occurs in two forms deep-vein thrombosis and pulmonary embolism. The annual rate of Deep Vein thrombosis urban areas is reported to be 0.5-1.6 in every 1000 people which is probably much higher in reality due to asymptomatic forms of the disease. Despite the high prevalence of Deep vein thrombosis in Ethiopia, there is a scarcity of published data on prevalence, factors contributing for treatment outcome of deep vein thrombosis particularly at Hiwot Fana comprehensive specialized University Hospital. Therefore this study aimed to assess the prevalence, treatment outcome and associated factors of deep vein thrombosis among patients visiting Hiwot Fana Comprehensive Specialized University Hospital, Harar, Eastern, Ethiopia. Objective: To determine the prevalence, treatment outcome and associated factors of deep vein thrombosis among patients visiting Hiwot Fana Comprehensive Specialized University Hospital Harar, Ethiopia from June 30, 2020 to June 30, 2024 .The data will be collected from December 20, 2024 to 01, January 20, 2025. Institutional based cross-sectional study will be undertaken among 261 Deep Vein Thrombosis patients visiting Hiwot Fana Comprehensive Specialized Hospital during the study period of June 30, 2020 to June, 2024. A total of 261 Deep vein thrombosis patients from this study period will be reviewed using a structured checklist. Simple random sampling technique will be used to select patients’ chart. The collected data will be entered in to EpiData Version 3.8 and exported to statistical package for social science version 25 for analysis. Binary logistic regression model will be used. All covariate which have P-value less than 0.25 in bivariable analysis will be entered for multivariable analysis and said to be significantly associated if P-value is less than 0.05 and strength of association will be presented by an adjusted odd ratio with 95% confidence interval. Expected Outcome: At the end of study high prevalence and good outcome will be expected among Deep Vein Thrombosis patients visiting Hiwot Fana Comprehensive specialized hospital. Additionally, the associated factors that significantly related with Deep vein thrombosis outcomes will be also identified. Estimated Budget: The budget calculated is 25,000 (twenty-five thousand birr) and it will be funded by Haramaya University 38p.

GESTATIONAL WEIGHT GAIN AND ASSOCIATED FACTORS AMONG PREGNANT WOMEN ATTENDING ANTENATAL CARE IN PUBLIC AND PRIVATE HEALTH FACILITIES IN GAROWE, PUNTLAND, SOMALIA

Mon, 01 Sep 2025 00:00:00 GMT

GESTATIONAL WEIGHT GAIN AND ASSOCIATED FACTORS AMONG PREGNANT WOMEN ATTENDING ANTENATAL CARE IN PUBLIC AND PRIVATE HEALTH FACILITIES IN GAROWE, PUNTLAND, SOMALIA HAFSO FARAH MIRE (BSC); Mr. Berhe Gebremichael (MPH, Assistant Professor); Dr. Tesfaye Assebe (PhD. Associate Professor) Background: The weight gained during pregnancy is known as gestational weight gain, which is a normal physiological process that support the increased metabolic demands of pregnancy as well as fetal growth and development. However inappropriate GWG is significant public health concerns, as it has been linked to adverse pregnancy outcome and increases the risk of future obesity and chronic disease in women. Evidence regarding gestational weight gain is scarce in Somalia, particularly in the Garowe City. Objectives: To assess the level of gestational weight gain and associated factors among pregnant women attending antenatal care in public and private health facilities in Garowe City, Puntland, Somalia, from July 15 to August 15 2024. Methods: An institution- based cross-sectional study was conducted on 412 systematically selected pregnant women in selected public and private health facilities in Garowe district of Puntland, Somalia. Data were firstly entered into kobo Toolbox, cleaned in Excel, and then exported to Stata version 17 for analysis. Data was collected using pretested and structured questionnaire. Descriptive statistical analysis, including simple frequencies, percentages, mean and standard deviation were used to describe participants’ characteristics .Information was presented using text descriptions, tables and figures. Binary logistic regression was fitted to identify the factors associated with gestational weight Gain. Level of statistical significance was declared at p- value<0.05 in the multivariable analysis, reporting adjusted odds ratio with 95% confidence intervals (CI) Result: The study showed that the mean gestational weight gain of the women was 8.22 kg (SD=1.73), and 57.35% (95% CI 52.4%, 62.08%) of the women had inadequate gestational weight gain. No formal education (AOR=2.00, 95% CI: 1.02, 3.77), multi gravidity (AOR=5.47, 95% CI: 1.91, 15.58) and lower early pregnancy body mass index (underweight) (AOR=5.32, 95% CI: 3.06, 9.26) were significantly associated with inadequate gestational weight gain. Conclusions The finding of the study revealed a higher magnitude of inadequate gestational weight gain. Being underweight at early pregnancy and lack of adequate food was positively associated with inadequate weight gain. These results highlight the importance of addressing pre-pregnancy BMI, ensuring a balanced diet. 89

LINEAR GROWTH FAILURE AT BIRTH AND ASSOCIATED FACTORS AMONG NEWBORNS DELIVERED AT PUBLIC HOSPITALS OF WEST HARERGHE ZONE, OROMIA REGION, ETHIOPIA

Sun, 01 Jun 2025 00:00:00 GMT

LINEAR GROWTH FAILURE AT BIRTH AND ASSOCIATED FACTORS AMONG NEWBORNS DELIVERED AT PUBLIC HOSPITALS OF WEST HARERGHE ZONE, OROMIA REGION, ETHIOPIA HABTAMU TESFAYE (BSC.); Dr. Anteneh Berhane (Ph.D.); Dr. Maleda Tefera (Ph.D.) Introduction: Growth failure at birth, shown by low birth weight and small size for gestational age, is a serious public health problem that increases the risk of newborn illness, death, and long term developmental issues. However, there have been few studies addressing this issue in the West Harerghe Zone, Oromia. Objectives: This study aimed to assess the prevalence of growth failure at birth and to identify associated factors among newborns delivered at public hospitals in West Harerghe, Oromia, Ethiopia, from February 5 to March 30, 2025. Methods and Materials: A facility-based cross-sectional study was conducted among 387 neonates born at randomly selected public hospitals in West Harerghe Zone, Oromia region, from February 5 to March 30, 2025. Participants were selected using systematic random sampling technique. Data were collected using the KoBoTool mobile application and data analysis was performed using SPSS version 26. Descriptive statistics was employed to summarize the data, and multivariable logistic regression was used to identify factors associated with growth failure at birth, by estimating AOR with 95% confidence intervals (CI) calculated and statistical significance set at p < 0.05. Results: The prevalence of growth failure at birth was 28.2 % (95% CI: 23.8, 33.1). Newborns from food-insecure households (AOR = 4.5; 95% CI: 1.7–11.7), mothers who had a mid-upper arm circumference (MUAC) less than 23 cm (AOR = 3.2; 95% CI: 1.1–9.5), and maternal age 20 34 (AOR = 6.5; 95% CI: 2.3-18.8) were significant associated factors with growth failure at birth Conclusion and recommendation: More than one in four newborns in the study area experienced growth failure at birth, highlighting it as a significant public health issue. Maternal nutritional status and household food security were identified as key contributing factors. Therefore, targeted nutritional support for pregnant women and improved food security are essential to mitigate this problem. 88