Abstract:
Background: Tuberculosis (TB) is one of the top 10 causes of death worldwide and the leading cause 
of death from a single infectious agent. In 2019, about 10 million people developed TB and 1.4 
million died in the world. Currently, Ethiopia is one of the 30 high TB burden countries and also one 
of the 14 countries within the three lists of the new WHO classification of high burden countries. 
Comparing the Tb incidence of study area with zonal and national level, for three consecutive years 
starting from 2017, it was by far higher than both zonal and national incidence each year. But the 
determinant factors were not studied in this district. 
Objective: To assess determinants of smear positive pulmonary tuberculosis in public health 
facilities of Odo shakiso district, Guji Zone, Oromia regional state, Ethiopia, June 2021.
Methods: A facility based case control study was conducted from 15-30 June 2021 among 118 
cases and 236 controls in Odo shakiso district. The sample size was estimated by OPEN EPI 
statistical software and proportionally distributed to health centers based on their case loads. 
Cases were randomly selected while controls were systematically. Data was entered to Epidata 
and analyzed by SPSS version 22. Bivariate and multivariate logistic regression analyses were
performed to assess the associated factors. Odds ratio with 95% CI was used to address the 
strength of association between dependent and independent variables. Statistical level of 
significance was declared at p value < 0.05. 
Results: primary occupation of being miner (AOR: 5.8; 95% CI: 1.34-25.0), education status of 
not formally educated (AOR: 2.04; 95% CI, 1.1-3.8), being HIV positive (AOR: 3.6; 95% CI: 
1.18–11.2), having contact history with TB patient (AOR: 3.4; 95% CI: 1.87–6.36 and Body 
Mass Index <18.5 (AOR: 6.2; 95% CI: 3.5–11.07) were associated with smear positive 
pulmonary tuberculosis.
Conclusion: primary occupation of being miner, education status of not formally educated, being 
HIV positive, having contact history with TB patient and BMI <18.5 was risk factors for smear 
positive PTB. Health, mining and energy and education sectors should work together to increase 
awareness of community there by halt tuberculosis transmission.