Abstract:
Background: Sexually transmitted infections remain a major public health problem in 
developing country including Ethiopia. University students are at high risk for acquiring sexually 
transmitted infections due to multiple factors shadowed. However, there is dearth of recent study 
conducted to assess the magnitude of the problem and its associated factors in Ethiopian 
Universities. 
Objective: The aim of this study was to assess the prevalence of sexually transmitted infections 
and its associated factors among undergraduate regular students in the Haramaya University, 
Eastern Ethiopia from March 1–30, 2023.
Methods: An institution based cross-sectional study was conducted among 778 randomly 
selected regular undergraduate students. A pre-tested structured and self-administered 
questionnaire was used to collect the data. Descriptive statistics was used to describe the 
dependent and independent variables. Bivariate and multivariable logistic regression analyses 
was employed using STATA version 17.0 to identify factors associated with sexually transmitted 
infections. Odds ratio with a 95% confidence interval was computed to determine the level of 
association. Variables with a p-value less than 5% was considered as statistically significant.
Results: In the current study, the prevalence of STI among university students was 25.40% [95% 
CI: 20.84, 30.56]. Bing female (AOR=2.06, 95% CI: 1.11, 3.80) and students from the college of 
computing and Informative (AOR=2.92, 95% CI: 1.32, 4.47), current khat users (AOR=2.20, 
95% CI: 1.09, 4.45) and current alcohol users (AOR=2.66, 95% CI: 1.32, 5.38), consistent 
condom use (AOR=0.21, 95% CI: 0.62, 0.74) , and poor knowledge about the mode of STI 
transmission (AOR=1.96, 95% CI: 1.04, 3.71) were important factors contributing to high 
prevalence of STI. 
Conclusions: The magnitude of STI among undergraduate regular students in Haramaya 
University was higher. Thus, reproductive health interventions targeting females and students 
from the college of computing and informatics, khat and alcohol users should be instituted.