Abstract:
Background:Child vaccination is one of the most cost effective public health interventions 
that reduces child morbidity and mortality.In most developing countries almost all top five 
disease for children morbidity and mortality were from vaccine preventable disease.(WHO, 
2022)According to district 2021/2022 annual reports, pneumonia was top five child morbidity 
and measles outbreak occur in different period of time in this study area.(Office, 2021/2022) 
Objective: To assess zero-dose status and determinant factors among children12–23-month
old in Deder district, Eastern Ethiopia from February1 to March1, 2024. 
Methods: Acommunity basedcross-sectionalstudy designwasconducted among randomly 
selected 431 respondents.The respondents drawn from 5 rural and 1 urban 
kebeles.Mothers/care givers with children 12-23 month old in the selected kebeles of the 
district was the study population and samples was selected by systematic random sampling 
methods, and zero dose children were those children who did not received any antigen of 
Penta-1.The data was collected by face to face interviewing mothers/care takers of child by 
using structured administered questioner. Collected data was entered into Epi-data and 
exported to SPSS, and analyzed by multinomial logistic regression. 
Results: The estimated zero dose vaccination prevalence was 15.37%,being from mothers 
with non-informal education increased the odds of being zero doseby AOR 8.1(95%CI: 1.05
10.01) and never attending ANC service increased odds of being zero dose by AOR 5.9 
(95%CI: 1.6-21.6).Traveling less than 60 minutes to vaccination center decrease the odds of 
zero dose by 80% AOR 0.2 (95%CI: 0.08-0.5), facility delivery decrease the odds of zero dose 
by 94%AOR 0.06 (95%CI: 0.03-0.14), having good knowledgedecrease the odds of zero dose 
by 97% AOR 0.03(95%CI: 0.01-0.07) and satisfying by service provided decreases the odds 
being zero dose by 94% AOR 0.06(0.03-0.12). 
Conclusion:Educational level, ANC, travelling time to reach vaccination site, Place of 
delivery, family size, satisfaction to service and knowledge status was the main determinant 
factors, thus focusing on improvement of quality service by strengthening sustainable outreach 
service.